Yi‐Lun Ying

Machine Learning-Assisted Discrimination of Isobaric Histone Acetylations by Nanopore

Abstract Histone acetylation, a post-translational modification, is associated with cancer progression, invasion, and metastasis, serving as a promising biomarker. The accurate discrimination of acetylation sites has strong potential for cancer diagnostics. Herein, we engineered...

Leveraging Electroosmosis in OmpF for Robust Peptide Sensing

Abstract Peptide sensing and sequencing are essential for elucidating sequence-function relationships and evaluating the peptide drug quality. Nanopore electrochemistry enables label-free characterization of peptide composition, structure, and interactions at the single-molecule...