Yihua Shi

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2 – JAM3 tight junction structure and the blood–brain barrier integrity

Abstract Primary brain calcification (PBC) is a neurodegenerative disorder characterized by bilateral brain calcification. JAM2 is a PBC causative gene, encoding the tight junction protein JAM2 and critical for blood–brain barrier (BBB) integrity, with an uncertain pathogenic mec...