Yichen Que

The Piezo1/Ca²⁺/NOTCH2 axis mediates matrix stiffness-induced osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Human bone marrow-derived mesenchymal stem cells (hMSCs) are key seed cells with multi‑lineage differentiation potential, and their osteogenic differentiation capacity forms the basis of bone regeneration. Extracellular matrix stiffness acts as a potent biophysical cue directing...