Yian Guan

Lysosomal homeostasis maintained by DCPS-mediated SLC4A7 splicing confers dependency in glioblastoma stem cells

Abstract Glioblastoma (GBM) is an aggressive brain tumor driven by GBM stem cells (GSCs), which lack therapeutic targets. Here, we identify RNA decapping enzyme DCPS as an essential regulator of GSC maintenance and GBM progression. Epigenetically regulated DCPS expression levels...