Yi-Zhi Lian

Dynamic 5-hydroxymethylcytosine remodeling associated with synaptic gene programs in the striatum of a Parkinson’s disease mouse model

The striatum, a key structure within the basal ganglia, undergoes functional dysregulation following the loss of dopaminergic input, contributing to the motor symptoms of Parkinson’s disease (PD). However, the involvement of DNA hydroxymethylation in striatal dysfunction remains...