Yi Xiao

Lactate suppresses innate immunity in Caenorhabditis elegans by excessive activation of SKN-1 associated with histone H4K16 lactylation

Histone lactylation is a recently identified epigenetic modification that directly couples cellular metabolic state with gene expression. Whether lactate affects host resistance to pathogens via histone lactylation remains unclear. Here, we found that infection with Pseudomonas a...