Yi Tien Yang

Hydantoin Impurity Formation During Peptide N-Terminal Acetylation with Acetic Anhydride

Abstract Previously unreported N-terminal hydantoin and N-acetyl hydantoin impurities were observed during peptide N-terminal acetylation with acetic anhydride under commonly used base/solvent conditions. The impurities were isolated and structurally characterized by HRMS and NMR...