Yi Qin Gao

JustEvo: A Prior-Guided Adaptive Mixture-of-Experts Framework for Multifunctional Protein Directed Evolution

Abstract Machine-learning-guided directed evolution can reduce the experimental burden of protein engineering by prioritizing variants before they are tested. In practice, however, many campaigns begin with few or no target-specific measurements, face choices about how to use het...

Potential structure induced effects of the hairpin motif in RNA to form the phase separated droplet like associate in different solution condition

Reversible associations of RNAs among themselves, or with RNA binding proteins through the process of phase separation, are found to be important in many different cellular contexts, including cellular responses to stress, gene regulation, development, and disease. Short RNA repe...