Yi Hua

Bioorthogonal Assembly of Cell-Nanoparticle Hybrids Enables Synergistic Cancer Therapy

Abstract Integrating nanoparticles (NPs) with living cells into a unified therapeutic system remains a major methodological challenge. Here, we describe a robust and modular bioorthogonal strategy for constructing cell-nanoparticle hybrids (CNHs) via sequential thiazolidine forma...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...