Y‐h. Taguchi

Reduced Detection of Human Orphan Gene Transcripts in Disease Tissue Relative to Expression- and Detection- Matched Controls

Human orphan genes are poorly annotated and lowly expressed, which makes their behavior in disease difficult to establish. We analyzed paired normal and disease RNA-seq libraries from four cohorts, quantified against a combined reference in which 2190 of 198,507 transcripts are o...

Interpretable integration of CITE-seq RNA and ADT profiles without explicit modality-weight tuning via tensor decomposition-based unsupervised feature extraction

CITE-seq jointly profiles cellular transcripts and surface proteins, but RNA and ADT modalities differ markedly in dimensionality, sparsity, and noise characteristics. We applied tensor-decomposition-based unsupervised feature extraction to paired CITE-seq data by constructing a...