Yezdan Fırat

Transferability of Transcriptome-Based Gene-Dependency Models from Two-Dimensional Cancer Models to Patient-Derived Organoids: Blinded External Validation

Transferability of transcriptome-based gene-dependency models from two-dimensional cancer models to organoids remains uncertain. Expression-only Elastic Net models for 20 preselected genes were selected using patient-grouped nested cross-validation in 681 models and evaluated in...