Ye Gong

1,2- seco -Bicyclic Polyprenylated Acylphloroglucinols as Isoform Selective Inhibitors of T-Type Calcium Channels

Abstract Hyreptaones A–E (1–5, respectively), five undescribed 1,2-seco-bicyclic polyprenylated acylphloroglucinols (BPAPs), were discovered in Hypericum reptans. 1–3 constitute the first 1,2-seco-BPAPs originating from rare 3,3-diisoprenylated BPAPs. 4 and 5 possess a spirocycli...