Yasin Uzun

Landscape and mutational dynamics of G-quadruplexes across the complete human genome

Abstract Background G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read based genome assemblies...

BEAR-GRN: Systematic assessment of single-cell multi-omics-based gene regulatory network inference methods

Identifying regulatory gene interactions is inherently challenging as it depends on both the transcriptional and epigenetic landscapes. Multiple methods are proposed to infer gene regulatory networks (GRNs) using single-cell multi-omics data, yet the absence of a standardized ben...