Yashwantsinh S. Jadeja

Design and Synthesis of Purine–Biphenyl Hybrids: Cytotoxicity, ADMET Analysis and MD Simulation Study

A novel series of purine–biphenyl hybrids was designed and synthesized by linking 2,6-dichloropurine with methyl-2-cyanobiphenyl, aiming to develop cytotoxic agents targeting the Epidermal Growth Factor Receptor (EGFR). Structural diversity was introduced via C6 substitution with...