Yaseen shah Shah

Prioritizing MSH6 Missense Variants of Uncertain Significance Using Integrated Computational and Population Evidence

MSH6 is a DNA mismatch-repair gene whose loss-of-function variants raise the lifetime risk of colorectal andendometrial cancer. Of the thousands of MSH6 variants in ClinVar, many remain classified as variants of uncertainsignificance (VUS). This project collected all 4,007 uncert...

Prioritizing MSH6 Missense Variants of Uncertain Significance Using Integrated Computational and Population Evidence

MSH6 is a DNA mismatch-repair gene whose loss-of-function variants raise the lifetime risk of colorectal andendometrial cancer. Of the thousands of MSH6 variants in ClinVar, many remain classified as variants of uncertainsignificance (VUS). This project collected all 4,007 uncert...