Yanyan Li

Mechanism-Guided Antimicrobial Peptide Design through Membrane-Surface Fingerprinting and Graph Diffusion

Abstract Antimicrobial peptides (AMPs) are promising antibiotic alternatives, but current AI-based discovery often relies on sequence labels and lacks explicit modeling of peptide–membrane interactions. We developed Membrane-MaSIF, an MD-derived membrane surface matching model de...

Origin, Conservation and Functional Diversification of the BES1/BZR1 Gene Family During Early Land Plant Terrestrialization in Bryophytes

BRI1-EMS-SUPPRESSOR 1 (BES1)/BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factors serve as core regulators of brassinosteroid (BR) signal in seed plants, where they control diverse developmental processes, including cell elongation, vascular development, and environmental respon...