Yanjin Wang

Integrated single-cell and bulk transcriptomic profiling identifies mannose metabolism-related biomarkers in Parkinson's disease

Abstract Parkinson's disease (PD) is a major neurodegenerative disorder after Alzheimer's disease, yet the molecular alterations driving its onset and progression remain only partly understood. Although mannose metabolism has been linked to nervous-system dysfunction, its contrib...

HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI–CKD progression

Abstract Histone deacetylase 4 (HDAC4) modifies both histone and non-histone proteins, but its role in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains unclear. Here, we investigated the function and mechanism of HDAC4 in ischemia–reperfusion...