Yang Yang

The Glycolysis-NETosis Feedback Loop: A Metabolic-Immune Axis in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory condition of the gastrointestinal tract with rising global incidence. Neutrophils, as first-line responders to intestinal inflammation, release neutrophil ex...

The bidirectional Thymus-Gut Axis: redefining central tolerance in digestive autoimmunity

Digestive autoimmune diseases impose an escalating global burden, largely because current therapies predominantly target downstream inflammation rather than primordial defects in immune tolerance. The thymus establishes central tolerance through stringent T cell selection and thy...