Yang Yang

Diastereo- and Enantioselective Photobiocatalytic α-Alkylation of α-Heteroaryl Amines Enabled by Pyridoxal Photochemistry

Abstract We report a photobiocatalytic system for the enantio- and diastereoselective α-alkylation of α-heteroaryl amines, a largely underexplored class of synthetically valuable non-native amine donors. Evaluation and directed evolution of thermophilic threonine aldolases, enabl...

Photometallobiocatalytic Asymmetric Radical‐Mediated Cross‐Coupling of Organotrifluoroborate Salts and Pyridotriazoles

ABSTRACT The cooperative integration of photoredox catalysis and metalloenzyme catalysis has emerged as a powerful strategy for enabling stereoselective radical transformations beyond the capabilities of either catalytic mode alone. Herein, we report a photometallobiocatalytic en...