Yang Wang

HTR1D triggers osteosarcoma metastasis and doxorubicin resistance via c-MYC/MAPK feedback and CCL2/5-HT-mediated M2 polarization

Osteosarcoma (OS) treatment remains hindered by frequent metastasis and resistance to doxorubicin, the standard chemotherapeutic. Despite multimodal therapy, survival for advanced disease is dismal. Identifying molecular drivers that concurrently regulate invasion and chemoresist...