Yang Shen

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

Development of a urine-based DNA methylation assay for early endometrial cancer detection: a multicenter diagnostic study

Endometrial cancer (EC) incidence is rising globally, yet diagnosis still depends on invasive procedures, which limit accessibility and delay early detection. A noninvasive, accurate, and accessible diagnostic assay is urgently needed to enable early EC detection. In this multice...