Yanfeng Zhou

Multikilogram-Scale Process Development for a Key Intermediate of a Clinical-Stage MTA-Cooperative PRMT5 Inhibitor

Abstract A multikilogram-scale, scalable, and cGMP-compliant synthesis of 4-aminoimidazo[1,5-a]quinoxaline-8-carboxylic acid (TM), a key intermediate for the MTA-cooperative PRMT5 inhibitor GTA182, has been developed to address the limitations of the original medicinal chemistry...