Yan Wang

Targeting Metabolic Pathways to Direct T-Cell Trafficking: Therapeutic Perspectives

Despite advances in immunomodulatory therapies, dysregulated T-cell trafficking persists as a pathological cornerstone in chronic inflammation, autoimmunity, and cancer. This spatially precise navigation—orchestrated by receptor–ligand cascades—ensures immune surveillance but dri...

Hyperopic reserve depletion and myopia burden among primary school students in Xingtai, China, 2 years post-covid-19: a cross-sectional study with refraction validation

Myopia has become a global public health crisis with an annual economic burden of up to $202 billion. Hyperopic reserve (HR) plays a pivotal role in myopia prevention, as excessive near-work in children depletes physiological HR, accelerates emmetropization, and leads to early my...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...