Yan-Jiang Wang

IgG depletion by FcRn blockade is associated with changes in amyloid pathology and neurodegeneration in APP/PS1 mice

Abstract Background Autoimmune disorders are associated with an increased risk of developing Alzheimer’s Disease (AD). Dysregulated autoantibodies have been suggested to contribute to exacerbated amyloid-beta (Aβ) accumulation. Based on the potential contribution of humoral immun...