Yan Chen

Cyclic nucleotide signaling through phosphodiesterase 1 inhibition and its interaction with the competing endogenous RNA network regulates cognition

Background Phosphodiesterase 1 (PDE1) has been demonstrated to be a potential drug target for a variety of diseases, ranging from peripheral system disease (PSD) to central nervous system disorders (CNSD). However, how cyclic nucleotide signaling, regulated by PDE1, particularly...

Numerical Simulation and Characteristics Study of Near-Field Fan Jet Breakup in Airless Spraying

The breakup process of near-field jets in airless spraying directly determines the initial droplet size distribution and macroscopic spray pattern, making it a critical factor af-fecting coating quality. This study establishes a numerical model for near-field atomi-zation based o...

Numerical and Experimental Investigation of Dynamic Air-Assisted Spray Deposition Characteristics on Horn-Shaped Surface

To address the challenge of uneven coating deposition during air-assisted robotic spraying on horn-shaped surfaces, a gas–liquid coupled numerical model was developed using the Euler–Euler multi-phase flow approach and subsequently validated through experimentation. Two dynamic s...