Yafang Chen

Design and synthesis of 1,2,4-oxadiazole-functionalized funtumine derivatives as potent anticancer agents

A series of innovative 1,2,4-oxadiazole-functionalized funtumine derivatives were designed, synthesized, and assessed for their antiproliferative effects on HCT116, HeLa, and HepG2 human cancer cell lines to discover new natural product-derived anticancer agents. The majority of...

Advances in collagen-based materials for tissue-engineered meniscus

Meniscus possesses weak self-repairability once getting hurt due to heterogeneity, particularly “white region” of avascular parts. However, the effect of conventional therapies in restoring structure and function of the meniscus isn’t ideal. Collagen, a key part of the extracellu...