Yadan Shi

Active LysosomalNanoplatform for Ferroptosis-EnhancedImmunotherapy via Tumor Extracellular Matrix Remodeling

Abstract The therapeutic efficacy of nanomedicines in solid tumors is often limited by rapid systemic clearance, dense extracellular matrix (ECM) barriers, poor tumor cell selectivity, and an immunosuppressive tumor microenvironment. Herein, we report an active lysosome-encapsula...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...