Xumu Zhang

Acetylated KLF5 as a therapeutic target mediating the anti-metastatic effects of doxycycline and methacycline in prostate cancer bone metastasis

Bone metastasis is a common and lethal complication of breast, prostate, and lung cancers. TGF-β in the bone microenvironment is pivotal for metastatic progression. We previously demonstrated that TGF-β induces acetylation of KLF5 at K369 and that acetylated KLF5 (Ac-KLF5) drives...