Xueqin Zeng

Piezo1-centered mechanotransduction in knee osteoarthritis: multicompartment mechano-inflammatory networks and therapeutic opportunities

Abstract Knee osteoarthritis (KOA) is increasingly recognized as a whole-joint mechano-inflammatory disorder in which abnormal loading, tissue remodeling, and inflammatory sensitization reinforce one another. Piezo1 is a context-dependent mechanotransduction hub that links mechan...