Xue‐Qiang Wang

Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmabl...

Beyond In Vitro Brightness: A Matched-Probe Study of Chemiluminescence Contrast for In Vivo Peroxynitrite Imaging

Probe selection for in vivo chemiluminescence imaging commonly relies on intensity and tissue-overlay measurements performed in vitro, yet these measurements do not reproduce the activation background, probe distribution, and optical environment of a living animal. Here, we test...