Xuehan Zhao

APEX1 deficiency impairs oocytes quality by disrupting mitophagy and activating ferroptosis in diminished ovarian reserve

Diminished ovarian reserve (DOR) is pathological condition characterized by reduced oocyte quantity and quality. Due to the complex etiology and limited therapeutic options, clarifying the underlying molecular mechanisms is critical. Oxidative stress has emerged as a pivotal cont...

The role of SAM-dependent internal m7G modification of LINC01252 in the progression of hepatocellular carcinoma

Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G)...