Xuefeng Huang

A Cervicogenic Mechanical–Glymphatic Shared Subtype Hypothesis of Bipolar Depression: A Theoretical Extension Based on the Investing Fascia–Carotid Sheath–Six-System Coupling Framework

Depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) overlap considerably in clinical presentation, making differential diagnosis challenging. Existing models have largely focused on central and molecular levels, with little systematic investigation of...

A Cervicogenic Mechanical–Glymphatic Shared Subtype Hypothesis of Bipolar Depression: A Theoretical Extension Based on the Investing Fascia–Carotid Sheath–Six-System Coupling Framework

Depressive episodes in bipolar disorder (BD) and major depressive disorder (MDD) overlap considerably in clinical presentation, making differential diagnosis challenging. Existing models have largely focused on central and molecular levels, with little systematic investigation of...

The Investing Fascia–Carotid Sheath–Six-System Coupling Hypothesis: A New Framework for the Cervicogenic Mechanical Pathogenesis of Anxiety Disorders and Depression

Classical pathogenetic mechanisms of anxiety disorders and depression involve monoamine neurotransmitter imbalance, hypothalamic–pituitary–adrenal (HPA) axis hyperactivation, neuroinflammation, decreased neuroplasticity, gamma-aminobutyric acid (GABA)/glutamate excitatory–inhibit...

The Investing Fascia–Carotid Sheath–Six-System Coupling Hypothesis: A New Framework for the Cervicogenic Mechanical Pathogenesis of Anxiety Disorders and Depression

Classical pathogenetic mechanisms of anxiety disorders and depression involve monoamine neurotransmitter imbalance, hypothalamic–pituitary–adrenal (HPA) axis hyperactivation, neuroinflammation, decreased neuroplasticity, gamma-aminobutyric acid (GABA)/glutamate excitatory–inhibit...

A Unifying Hypothesis: The Investing Fascia as a Mechanical Hub in Neurodegenerative Diseases—A Theoretical Framework Integrating the "Eight-Tier Evidence Pyramid" and "Six-System Interplay"

The present study draws on available evidence to propose the "cervicogenic investing fascia mechanical constraint" hypothesis, employing an integrated argumentative framework with the "Eight-Tier Evidence Pyramid" as its structural backbone and the "Six-System Interplay" as its m...