Xuanyi Li

Harnessing the Silicon Effect for Copper-Catalyzed Linear- E -Selective Reductive Coupling of Ketones with Allenylsilanes

Abstract We report a copper-catalyzed reductive coupling of ketones with allenylsilanes that delivers γ-silyl homoallylic alcohols with exceptional linear E-selectivities. Mechanistic investigations indicate that the silyl substituent functions as a directing element for regiosel...