Xiyuan Liu

Lacrimal Secretory Niche Remodeling in Dry Eye Disease: Single-Cell and Spatial Insights into Acinar Dysfunction

Reduced tear output can arise from altered neural regulation, impaired epithelial secretion, or loss of secretory tissue, with different implications for recovery. This focused narrative review integrates physiological, single-cell, spatial, organoid, and mechanistic studies iden...

3D epigenomic landscape of the human retinal pigment epithelium

The retinal pigment epithelium (RPE) is crucial for visual function, and its dysfunction contributes to retinal diseases such as age-related macular degeneration. Despite the translational potential of iPSC-derived RPE (iPSC-RPE) in cell replacement therapy, the functional visual...