Xiuhui He

Lactate-induced H3K9 lactylation disrupts the inner blood–retinal barrier by activating the PTK2–FMNL2 axis in diabetic retinopathy

Disruption of the inner blood–retinal barrier (iBRB) is a major cause of vascular leakage and vision impairment in diabetic retinopathy (DR), yet the metabolic mechanisms driving endothelial barrier failure remain incompletely understood. Here, we investigated whether lactate-ind...