Xinyue Dai

Discovery of Stereoselective UrCYP71AU Oxidases Catalyzing the Final Biosynthetic Step of Rhynchophylline and Mechanistic Insights into 7R and 7S Spiroindole Skeleton Formation

Abstract Rhynchophylline (RHY) is a spiroindole alkaloid that acts on the cardiovascular and central nervous systems. Based on the distribution patterns of 7R and 7S spiroindole alkaloids in U. rhynchophylla, we hypothesize the existence of hirsutine oxidase responsible for 7R an...

Bioactive polysaccharides from the industrial crop Platycodon grandiflorus restore intestinal barrier integrity and suppress bEVs-mediated pyroptosis: A functional component for respiratory health management

Platycodon grandiflorus is widely recognized as an industrial crop due to the high value of its bioactive polysaccharides (PGP). Despite its traditional use for pulmonary and gastrointestinal health, the underlying mechanisms remain poorly defined. This study investigated whether...