Xinying Guo

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells in systemic lupus erythematosus and averts glomerular pathology

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation in multiple organ systems. Although elevated circulating levels of the hormone/cytokine prolactin (PRL) have long been associated with increased SLE activity, the extent to...

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells in systemic lupus erythematosus and averts glomerular pathology

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation in multiple organ systems. Although elevated circulating levels of the hormone/cytokine prolactin (PRL) have long been associated with increased SLE activity, the extent to which dif...