Xining Sun

Structural Modification of Bifenox Derivatives: Discovery of Novel Diaryl Thioethers as Potent Insect Trehalase Inhibitors

Abstract To discover novel noncarbohydrate trehalase inhibitors, 62 bifenox derivatives were designed and synthesized in this study. Among them, diaryl thioether 2b-1 exhibited optimal trehalase inhibitory activity with 72.5% inhibition rate at 100 μM and a Ki value of 36.3 μM, s...