Xingyi He

Machine learning combined with multidimensional validation identifies SNCA and NR2F2 as key hubs implicated in paraquat and rotenone co-exposure-induced Parkinson’s disease

Combined exposure to pesticides, such as paraquat (PQ) and rotenone (Rot), is a significant risk factor for Parkinson’s disease (PD). However, the synergistic pathogenic mechanisms underlying their co-exposure remain largely elusive. This study aimed to elucidate the key molecula...