Xingjie Zan

Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery

Abstract Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution,...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...