Xingdi Cheng

Kinetically ProgrammedThermoresponsive PolyethyleneGlycol Shedding from Lipid Nanoparticles Improves mRNA Delivery

Abstract Polyethylene glycol (PEG) can stabilize nanoparticles and facilitate transport across biological barriers, yet the same PEG layer suppresses cellular uptake─a trade-off known as the PEG dilemma. Current strategies seek to overcome this limitation by enabling PEG shedding...