Xin Zhang

Homoharringtonine suppresses cervical cancer progression through modulation of the EGFR/PI3K/AKT/mTOR signaling pathway

Homoharringtonine (HHT), a natural alkaloid approved for treating hematological malignancies, has shown potential activity against solid tumors, but its role in cervical cancer remains unexplored. This study investigates the anti-cervical cancer effects of HHT and its impact on t...

Impact of preanalytical variables on urinary cell-free DNA quality: Centrifugation, EDTA concentration, storage and thawing strategies

Abstract Background Urinary cell-free DNA (ucfDNA) holds promise for liquid biopsies, yet standardized preprocessing protocols are lacking. This study evaluated the impact of several preanalytical variables on ucfDNA quality: ethylenediaminetetraacetic acid (EDTA) concentration,...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...