Xin Le

Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing

Sepsis involves dysregulated host responses with mitochondrial dysfunction as a key mechanism, yet its immune cell landscape and clinical utility are unclear. We integrated five GEO datasets (GSE65682, GSE95233, GSE54514, GSE26440, GSE26378) comprising 1,256 samples. Mitochondria...