Xin Ji

Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation

Selective 5-HT2AR agonism without 5-HT2BR activation is critical for safe psychedelic-inspired therapeutics. Here, we systematically probe the ligand-binding pockets of 5-HT2AR and 5-HT2BR and identify steric and conformational constraints at the side-extended pocket (SEP) and ex...

Enantioselective and Divergent Synthesis of Propargylamides and Allenamides from Alkynyl Diazoketones and Anilines via Organocatalytic Wolff Rearrangements

Abstract Chiral allenes and alkynes are privileged scaffolds in natural products and pharmaceuticals. Although significant advances have been achieved in catalytic asymmetric synthesis from diazo compounds, selectively achieving high levels of both enantioselectivity and regiosel...