Xin Chen

Autophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake

Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation; however, how selective autophagy regulates ferroptotic sensitivity remains incompletely understood. Here, we identify RAB8A as a selective autophagic substrate and negative regulator of fe...