Xiaoyu Gou

Type I and II pili mediate transcytosis of Streptococcus pneumoniae across blood-brain barrier cells in the pathogenesis of pneumococcal meningitis

Streptococcus pneumoniae , a common pathogen to cause pneumonia and otitis media, is also the most important causative agent of bacterial meningitis in humans. Previous studies have shown that S. pneumoniae strains can be pilus-negative, type I pilus- and/or type II pilus-positiv...