Xiaoying Fan

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice

Abstract Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly...