Xiaoyan Gu

Supraphysiological Citrate Exposure Drives Nonmonotonic Immunometabolic Reprogramming and Proinflammatory Activation in Monocytes/Macrophages

ABSTRACT Patients receiving continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA) frequently experience systemic citrate accumulation, yet its immunometabolic consequences remain poorly understood. Here, we examined how supraphysiological citrate...