Xiaoxuan Zhu

MCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation

Abstract DNA replication initiation requires activation of the CMG helicase to establish the replisome. This process involves the extrusion of single-stranded DNA (ssDNA) from the central channel of MCM double hexamers, allowing the two CMG helicases to pass each other; however,...