Xiaowen Zhang

Single-cell transcriptomics and functional validation reveal a TUBB4B-associated malignant epithelial state in nasopharyngeal carcinoma

Intratumoral heterogeneity of malignant epithelial cells limits prognostic stratification and therapeutic development in NPC, yet transcriptionally distinct malignant epithelial states and their associated molecular programs remain poorly characterized. We aimed to identify clini...

Exploring multidimensional cfDNA methylation fragmentomics for non-invasive postoperative assessment in early-stage lung cancer

Background Effective postoperative monitoring remains an important area of investigation for early-stage lung cancer patients after curative resection. This exploratory technical feasibility study evaluated a methylation-based fragmentomics approach by analyzing paired pre- and p...