Xiaowen Zhang

Multilevel Mechanisms and Clinical Efficacy of Psilocybin in Depression Treatment: A Systematic Review

Depression, characterized by persistent low mood and anhedonia, represents a prevalent affective disorder imposing substantial medical and economic burdens. Current first-line antidepressants are limited by delayed onset and treatment resistance. Psilocybin (PSI) has re-emerged a...

CD9 + B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

ABSTRACT Adenoid hypertrophy (AH) is associated with excessive proliferation of germinal center B (GC‐B) cells, yet the mechanisms underlying GC regression and termination remain poorly understood. This study used single‐cell RNA sequencing (scRNA‐seq) to profile the cellular com...

Single-cell transcriptomics and functional validation reveal a TUBB4B-associated malignant epithelial state in nasopharyngeal carcinoma

Intratumoral heterogeneity of malignant epithelial cells limits prognostic stratification and therapeutic development in NPC, yet transcriptionally distinct malignant epithelial states and their associated molecular programs remain poorly characterized. We aimed to identify clini...

Exploring multidimensional cfDNA methylation fragmentomics for non-invasive postoperative assessment in early-stage lung cancer

Background Effective postoperative monitoring remains an important area of investigation for early-stage lung cancer patients after curative resection. This exploratory technical feasibility study evaluated a methylation-based fragmentomics approach by analyzing paired pre- and p...